In this paper, we consider the problem of locating a Target Node (TN) moving along a corridor in a large industrial environment, by means of Ultra-Wide Band (UWB) signaling from fixed Anchors Nodes (ANs) uniformly positioned at the same height on both sides of the corridor. For a representative geometry of a large indoor (industrial) scenario, we formulate an analytical approach to the optimized placement (in terms of inter-node distance) of ANs, using the criterion of minimizing the average Mean Square Error (MSE) in the Time-Difference-Of-Arrival (TDOA)-based estimated positions of the TN. Under the assumption of a fixed variance of the range estimation error, we derive a simple closed-form expression for the optimal inter-AN distance in terms of the corridor width and the height of the ANs. The effectiveness of the analytical approach is confirmed by simulations. We also show that the proposed approach allows the MSE in the TN position estimates to reach the Cramer Rao Lower Bound (CRLB).